A Oku Selected Research

T 1095

4/2002	Normalization of cytoplasmic calcium response in pancreatic beta-cells of spontaneously diabetic GK rat by the treatment with T-1095, a specific inhibitor of renal Na+-glucose co-transporters.
5/2001	Inhibitory effect of hyperglycemia on insulin-induced Akt/protein kinase B activation in skeletal muscle.
1/2001	Improved diabetic syndrome in C57BL/KsJ-db/db mice by oral administration of the Na(+)-glucose cotransporter inhibitor T-1095.
12/2000	Antihyperglycemic effect of T-1095 via inhibition of renal Na+-glucose cotransporters in streptozotocin-induced diabetic rats.
11/2000	Correction of hyperglycemia and insulin sensitivity by T-1095, an inhibitor of renal Na+-glucose cotransporters, in streptozotocin-induced diabetic rats.
8/2000	T-1095, a renal Na+-glucose transporter inhibitor, improves hyperglycemia in streptozotocin-induced diabetic rats.
3/2000	Antidiabetic effect of T-1095, an inhibitor of Na(+)-glucose cotransporter, in neonatally streptozotocin-treated rats.
3/2000	Hyperglycemia contributes insulin resistance in hepatic and adipose tissue but not skeletal muscle of ZDF rats.

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A Oku Research Topics

Disease

6	Hyperglycemia 04/2002 - 03/2000
4	Insulin Resistance 05/2001 - 03/2000
2	Type 2 Diabetes Mellitus (MODY) 04/2002 - 01/2001
2	Body Weight (Weight, Body) 01/2001 - 11/2000
2	Diabetes Mellitus 12/2000 - 11/2000
1	Glucose Intolerance 01/2001
1	Albuminuria 01/2001
1	Diabetic Nephropathies (Diabetic Nephropathy) 01/2001
1	Diabetes Complications 01/2001
1	Glycosuria 12/2000
1	Hypoglycemia (Reactive Hypoglycemia) 12/2000
1	Neoplasms (Cancer) 02/2000

Drug/Important Bio-Agent (IBA)

8	T 1095IBA 04/2002 - 03/2000
5	Glucose (Dextrose)FDA LinkGeneric 04/2002 - 03/2000
4	Insulin (Novolin)FDA Link 04/2002 - 03/2000
4	Facilitative Glucose Transport Proteins (Glucose Transporter)IBA 05/2001 - 03/2000
3	Streptozocin (Streptozotocin)FDA Link 05/2001 - 08/2000
2	benzofuranIBA 01/2001 - 11/2000
2	Blood Glucose (Blood Sugar)IBA 01/2001 - 11/2000
1	Phosphatidylinositol 3-Kinases (PI 3 Kinase)IBA 05/2001
1	Proto-Oncogene Proteins c-akt (Protein Kinase B)IBA 05/2001
1	Therapeutic UsesIBA 01/2001
1	PhlorhizinIBA 01/2001
1	Hypoglycemic Agents (Hypoglycemics)IBA 12/2000
1	KetonesIBA 03/2000
1	Nonesterified Fatty Acids (NEFA)IBA 03/2000
1	SodiumIBA 03/2000
1	GurIBA 03/2000
1	Protein Serine-Threonine Kinases (Protein-Serine-Threonine Kinase)IBA 02/2000

Therapy/Procedure

1	Oral Administration 12/2000